Journal: Biomedicines

Article Title: Small Cell Lung Carcinoma: Current Diagnosis, Biomarkers, and Treatment Options with Future Perspectives

doi: 10.3390/biomedicines11071982

Figure Lengend Snippet: Most important genes altered in SCLC (mostly according to memorial Sloan Kettering-integrated mutation profiling of actionable cancer targets—MSK-IMPACT sequencing of SCLC tumors)—data adopted from Cheng et al. [ 29 ], Rudin et al. [ 23 ], and Liu et al. [ 30 ].

Article Snippet: KRAS , C-K-RAS , CFC2 , K-RAS2A , K-RAS2B , K-RAS4A , K-RAS4B , KI-RAS , KRAS1 , KRAS2 , NS , NS3 , RALD , RASK2 , K-ras , KRAS proto-oncogene, GTPase , c-Ki-ras2 , OES , c-Ki-ras , K-Ras 2 , K-Ras , Kirsten Rat Sarcoma virus , Chromosome 12 at position 12p12.1. 189 amino acids , Activating mutation , A GTPase involved in cell signalingpathways that regulate cell growth and proliferation ( RAS /MAPK). KRAS mutations can lead to the constitutive activation of the KRAS protein, resulting in dysregulated cell signaling and increased cell proliferation. , 1–3 , Otegui et al. [ ] Li et al. [ ] .

Techniques: Mutagenesis, Sequencing, Transformation Assay, Binding Assay, Expressing, Activity Assay, Fat, Migration, Virus, Activation Assay, Protein-Protein interactions, Gene Expression